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Produkter
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On-Line Electrochemistry/LC/MS
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oxmet01.pdf
Mimicking oxidative metabolism by electro-chemistry and identification of metabolites by (ESI) MS . The ideal system for automated analysis of numerous samples in metabolomics
•fast, synthesis •zero matrix effect, no isolation steps
•direct identification of oxidative labile sites in drug molecule
Applications EC/(LC)/MS
1. Signal enhancement in MS / Proteomics
2. Fast and Easy synthesis of metabolites (µ-preparative) within minutes vs. days or weeks using traditional methods
3.Rapid risk assessment of drug %u0336 protein binding
4. high throughput screening of metabolites
5.Electrochemical cleavage of proteins/peptides
6.Oxidative stress/damage of proteins, DNA, lipids, etc. (mimicking natures redox reactions)
7.Predicting drug/xenobiotic metabolism
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ROXY™ EC System
“The possibility of simulating the oxidative
metabolism of drugs is only one major reason
for the strongly increasing attraction in the
on-line coupling between electrochemistry
and electrospray mass spectrometry (EC/MS) for both industry and academia.”
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ROXY™ EC System upfront MS
General conditions
ROXY™ EC is the ideal system for fast mimicking of oxidative metabolism of single compounds (phase I and II)
Features ROXY™ Line
ROXY™ Potentiostat
§Large working potential range, +/- 5 volt
§From 2 up to 4 reactor cells (simultaneous use of different working electrodes and/or potentials) upgradability
§Pulse mode for optimal reactor cell activation and cleaning
(working electrode)
§Scan mode for rapid measurements of the optimal conversion
potential e.g., Voltammogram
§Thermostated àoptimal conversion kinetics
ReactorCell
§Proprietary reactor cell to assure minimal sample adsorption
§Easy and quick working electrode replacement
§Large variety of working electrodes e.g., GC, Au, Pt, MD (Magic Diamond™)
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 Introducing the cHiPLC™-nanoflex system:
making nanoLC/MS easier and more reproducible
 The new cHiPLC-nanoflex, in combination with the nanoLC-Ultra systedelivers superior sensitivity, excellentm and any mass
spectrometer/nanospray source, column-to-column reproducibility, and ease of operation.
A "docking station" for up to three microfluidic chips, the system's flexible design and built-in 10-port nano valve allow for easy
switching between direct injection, trap-loading and dual column with direct injection experiments.
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CPS Disk Centrifuge
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Particle Size
CPS Disc Centrifuge, Models DC12000, DC18000, DC20000 and DC24000 - the world's fastest, highest resolution, and most sensitive centrifugal sedimentation particle size analyzers. Measure virtually any type of particle, between 0.005 and 75 microns, at 2 to 10 times better resolution than any other particle sizing instrument, regardless of measurement technique. The minimum reportable peak width can be less than 2% of peak diameter.
Here are a few of the many applications where the CPS Disc Centrifuge can be used:
- Chemical:
- Polymer latexes and emulsions
- Fillers (CaCO3, clay, barites, etc.)
- SiO2 dispersions
- Abrasives (of all types)
- Impact modifier particles
- Oil emulsions
- Pharmaceutical:
- Virus particles/virus-like particles
- Cells (culture) and cell fragments
- Protein clusters
- Liposome's
- Particles in diagnostic tests
- Micro-encapsulated drugs
- Semiconductor:
- Micro-abrasives
- CMP compounds for integrated circuits
- Printing and painting:
- Pigments - water and oil based
- Micro-fiber paint viscosity modifiers
- Printer/copier toner powders
- Inkjet inks
- Carbon black
- Magnetic iron oxide
- Others:
- Micro-spheres
- Agglomeration patterns
- Starch/flour particles
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ALEXYS LC-EC System
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Neurotransmitters, Clinical analyser, Carbohydrates,
Aminoglycosides, Disulfides, Azithromycin
Off-line systems
§ Dedicated and optimised for top performance!
§ Best detection limits, smallest sample use!
§ High efficiency; 2D, CS.
§ Highest sensitivity,
On-line systems
§ Simultaneous analysis for:
- Efficiency; parallel microdialysis
- Improved Time resolution
Clarity for Alexys
ALEXYS System Solutions for Neuroscience
GUARANTEED APPLICATION!!!
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NanoLC-Ultra™ system
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The NanoLC-Ultra family of high pressure HPLCs for proteomics research
The new NanoLC-Ultra is Eksigent’s third generation system, delivering superior gradient precision at pressures up to 10,000 psi.
The next generation NanoLC system from Eksigent promises to deliver high resolution separations, combined with excellent reproducibility, resulting in improved identification of low abundance peptides/proteins with nanoLC-MS.
Key advantages of the new NanoLC-Ultra:
Splitless, nano-scale flow control
10,000 psi maximum pressure
Retention time reproducibility
Peak parking
Mass spec software integration
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Maldi Spotting System
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Analysis of complex peptide and/or protein samples in proteomics
Coupling NanoLC to Maldi mass spectrometry provides an extremely powerful tool for the analysis of complex peptide and/or protein samples in proteomics.
The Ekspot spotter/fraction collector deposits fractions eluted from the NanoLC onto a MALDI plate, while a built-in pump automatically adds the matrix. High positioning accuracy ensures consistent spotting with maximum resolution.
By eliminating flow splitting, Eksigent's proprietary microfluidic technology improves reproducibility and sensitivity and eliminates solvent waste. The NanoLC's precise microscale flow control runs HPLC gradients at rates as low as 20 nL per minute. |
Automation for LC / GC and LC-MS
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Syringe only technology
The syringe only concept of the HTC PAL combines the manual sample injection procedure with the precision and throughput of a robotic liquid handling system. Samples are aspirated with a conventional syringe and are transferred directly into the sample loop. No error prone teflon tubing or transfer lines are involved during the sample loading process.
Advanced performance
The HTC PAL provides outstanding performance and maximum flexibility for your LC sample processing system. Sample capacity of > 600 2ml standard vials or up to 24 microplates within 50cm of benchspace are unmatched in the industry. Temperature controlled sample storage makes it easy to cool down samples to prevent degradation or to heat samples for kinetic studies. Using the optional 4 port or 10 port injection valve enables complex column switching procedures or internal loop configurations.
Intelligent system control
Choose between 3 options to control your HTC PAL instrument. The local handheld controller provides easy-to-learn, easy-to-use operation. For individual application requirements the PC based Windows 2000/XP control software Cycle Composer is available. For single keyboard operation of a whole LCMS system, various third party HTC PAL drivers are available. |
Chromatography Accessories and Supplies
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All of Applied Research tubing is extruded from virgin materials manufactured by the original manufacturer of each material. We do not allow substitutes for our raw materials.
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Applied Research SS fittings are manufactured different materials for both high and low pressure applications. We take a pride in our work and make sure that we only use the finest materials available.
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All of Applied Research metal filters are manufactured by Applied Porous Technologies. All other material is manufactured in our own facilities.
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Choose between Applied Research PEEK or SS column line in many different dimensions.
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When working in Chromatography you will need a kaleidoscope of tools. Applied Research offers you all the tools you are looking for.
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Beside Solvent Recycler, Degasser and other useful accessories, Applied Research Europe offers a line of manual injection and switching valves
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Rapid, high rapid throughput analytical
HPLC
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Life Science (metabolomics), Pharmaceutical (drug development & discovery)
Why use ultra-high pressure when you can use the ExpressLC-100 and consume less solvent, save money, cut analysis time in half and realize high resolution and sensitivity? Read about the results GSK achieved using the ExpressLC-100 for open-access LC/MS.
Use of the ExpressLC System for Peptide Separations
Acid-Induced Degradation of Steroids in Rat Chow
Use of the ExpressLC System for Chiral Drug Analysis
Accelerated Thermal Degradation of Indomethacin
High-speed Determination and Examination of High Molecular Weight Proteins with the ExpressLC System
Use of the ExpressLC System for Bioanalytical/ Pharmacokinetic Studies
Use of the Eksigent ExpressLC System to Measure Chromatographic Hydrophobicity Index
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NanoLC 2D
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Proteomics, Metabolomics, Biomarker discovery, phosphopeptide analysis
The NanoLC Proteomics system performs high-resolution separations of peptides before analysis by a mass spectrometer. The NanoLC system’s microscale flow control runs precise HPLC gradients at flow rates as low as 20 nL/min. Low flow rates provide maximum mass spectrometer sensitivity and contribute to the system’s ability to improve identification of low-abundance proteins.
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Alexys 110
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Analysis of catecholamines, serotonin, metanephrines, VMA, HVA and 5-HIAA in urine and/or plasma.
The Alexys 110 has been developed for routine analysis in clinical, environmental and pharmaceutical laboratories. The system comprises a Decade II SDC, autosampler, pump, organiser, bottle rack and data acquisition software. The organiser has integrated degassing, pulse damper and mains power distributor for all the devices. The Decade II SDC has the same performance as the Decade II with advanced digital filtering and control for a single flow cell in DC mode.
Complete kits are available consisting of column, mobile phase, sample prep, standards and calibrators.
Key Features
Fully controlled standardised system for
routine analysis
Built in solvent degassing and pulse control
Ability to analyse vials and well plates with cooling
Advanced digital filtering
Complete kits for the analysis of catecholamines, serotonin, metanephrines, VMA, HVA and 5-HIAA in urine and/or plasm
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Recipe
ClinRep® HPLC Complete Kits - Diagnostics / Therapeutic Monitoring |
Reference Materials, HPLC Complete Kits and HPLC Instruments for Medical Diagnostics.
§ Catecholamines in urine
§ Catecholamines in plasma
§ Serotonin in urine
§ Serotonin in plasma
§ Metanephrines in Urine
§ VMA, HVA, 5-HIAA in Urine
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Product areas within our core competency include:
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High Throughput Screening , Combinatorial Chemistry, Flow Injection Analysis, Pharmaco-kinetic studies, DMPK, ADMET
Interfaces with any major LC-MS system.
Fast injection cycle time.
Temperature controlled sample storage.
Front End Automation for LC and LC-MS microplate applications. Up to 24 microplates within 50/80 cm bench space.
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PRIM 500
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Learning spectrophotometry techniques in biologi and biochemistry schools, running routine tests in clinical, veterinary, food analysis laboratories...
Example of analysis methods
Substrates: Albumine, Alcool, Ammonia, Bilirubin, Calcium, Chloride, Cholesterol, HDL/LDLcholesterol, CO2, Creatinine, Iron, Magnesium, RBC magnesium, Phospho-lipids, Phosphorus, Total protein, Triglycerides, Urea, Uric Acid...
Enzyme: Acid/Alkalin, Phosphatase, Amylase, APO-Al, ASAT/GOT, ASAT/GTP, CK, CGT, LDH, Lipase, Nukleotidase...
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Pastel UV
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COD, BOD, TOC, TSS, NO3, SUR
*Multiparametric measure : Organic matter (COD, BOD,TOC,TSS) specific compounds (NO3, Detergents)
*All type of waters (Natural water, raw sewage water, treated water,process water)
*Fast, reading in less than 1 minute
*Convenient, easy-to-use
*Without reagent
*User friendly
Gross weight : 9Kg
Dimensions : 40 x 40 x 40 |
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AI 3200 AF Spectrometer
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Pharmaceutical, Clinical, Environmental, Agricultural, Geological & Metallurgical, Pretrochemical
Our Atomic Fluorescence Spectrometer offers a unique approach to vapor/hydride generation with ppt detection limits for Hg, Cd, Zn & the hydride forming elements and a linear dynamic range of 3 orders of magnitude. Capable of analyzing 11 different elements virtually free from matrix interferences. |
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AI 1200 AA Spectrometer
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AI 1200 Atomic Absorption Spectrometer
It is no accident that Aurora Instruments Ltd. has designed and built an Atomic Absorption Spectrometer hich combines unmatched features-for value with one of the smallest footprints in the industry.
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VERSA 3000
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Liquid Handling
The VERSA series delivers flexibility and maximal possibility in liquid handling with
its expandable and versatile design. This station automates multiple genomics,
proteomics, drug discovery and analytical applications
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2D iD Gel Processing System
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Proteomics
2D iD: 1D or 2D Gel Imager and Cutter
1D or 2D Gel Imager and Cutter (2DiD System); integrated imaging and gel cutting instrument. Imaging system based on high quality CCD camera and software selectable multi-light source illuminator.
ConsistsOf
Bench-top high precision robotic platform for gel plug excision, gel plug detection and multi-well plate collection. Complete with light filtering enclosure, fan, air filter (HEPA) and custom data processing hardware (PC) and software.
• Reliable Gel Plug Cutting
• Precise Gel Plug Excision
• High Quality Imaging
• Multiple Light Sources
• Software Selectable
• Compact Bench-Top Layout
• Solid Sturdy Design Features
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2D iD-x Slab Gel Imager and Spot Processor
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Proteomics
The 2D iDX is an XYZ robotic platform with Gel Imaging, Spot Cutting, Liquid Handling, Digestion and MALDI Spotting functions. It offers a highly cost effective, small footprint, high capacity solution to slab gel processing. The system uses state of the art linear motors with minimal moving parts. 2D iDX has high precision liquid handling capability and can use fixed or disposable tips. The fixed tip can wash on the fly to speed the process. Active plug sensing combined with automated error alarm and "try/retry" function eliminates downtime. The user-friendly software allows you to concentrate on the process and not the software. The robot also has multi-tool handling ability for moving plates and filtering processed gel plugs.
• Imaging and gel plug cutting in one
• Uses unique plug dedection system and
transluminator light source
• Capable of importing images and cut-lists from
other imaging equipment.
Fully automated gel processor
Large capacity
Active plug sensing
Images, cuts and digests
Spots to MALDI
Small footprint
Places multiple plugs into single well
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TMiD for Tissue maldi
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Biomarker Research/ Drug Development/ Comparative Proteomics
The TMiD is an XYZ Robotic Platform for preparing microtome tissue slices for MALDI Analysis. It offers a cost effective, small footprint, high capacity solution to tissue sample MALDI processing. The system uses state of the art linear motors with minimal moving parts. TMiD can image the tissue slice and spot drops down to 10nl with diameters of <200µm on the fly to speed the process. The software allows you to select arrays patterns automatically or manual by point and click. Spot patterns can be repeated to allow treatment with multiple reagents.
• High precision XYZ Stage 2-4 micron
reprocibility
• High resolution CCD Camera 1-5
micron/pixel
• Matrix dospensing system down to 3nl/spot
• Switch matrix automatically
• Wash dispense tip in ultrasonic bath
• 6-10 MALDI plate capacity
• 3 matrix reservoirs
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Optic 3
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Gas Cromatography - Injector
• Handles the widest range of applications
• Has unmatched flexibility for choice of
injections
• Programmed temperature and flow control
• Designed for full automation
• Easily installed
This instrument is used as Interface between sample and column to the mass spectrometer or other detectors with a very fast heating ramp up to 25 C/sec.
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CryoFocus 3
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Gas Cromatography
• Extreme low consumption of Liquid
Nitrogen
• More flexibility and precision
• Increase of sensitivity and speed
• User-friendly operation
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PAM Distillation full automatic distillation
Precision Automated Manual Distillation Unit
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Petroleum
> True Stand alone operation
> Fully automated operation
> True volume measurement
(without volume correction factors)
> Programmable with 'learn' feature
> Digital distillation temperature measurement
> Auto Cal Temperature probe
(with built in calibration data memory)
> Dynamic ASTM 7C/F and ASTM 8C/F thermometer simulation
> Automatic barometric pressure correction
(with built in pressure sensor)
> Automatic final boiling point detection and loss correction
> Solid state condenser tube cooling via Peltier elements
> Solid state receiver compartment cooling via Peltier elements
> Data port for data output to PC (LIMS)
> Printer port
> ORBIS Multipurpose Flask Support Board
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PHASER
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Gas Chromatography
Olfactometry (GC-O or Sniffer)
• No cold spot gives the possibility to sniff the high boiling compounds.
• Maximum 300ºC on the transfer line.
• Protects your nose from drying by adding
moisture air to sniffing port.
• Easy to connect the capillary column to the splitter.
• Sitting down while sniffing.
• Compact and easy to install on any
GC instrument.
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